Distinguished Professor Anatoly Rozenfeld is pleased to present the Centre for Medical Radiation Physics mid-year report, highlighting their success in publications, initiatives and grants.

It is a great pleasure to summarise what CMRP has achieved for the first half-year of 2020, in spite of difficulties associated with COVID 19.

It is amazing how dedicated all streams of CMRP have been to research and HDR student mentoring.  Our progress in research, PhD completions, grant preparation and collaboration with industry has not stopped.

This is reflected in the outstanding number of publications published; with more than 30 majority of top-ranked journals including two invited Topical Reviews in PMB and seminal contribution to Medical Physics journal on Geant4.  Thirteen submitted applications for competitive national and international grants, four ANSTO HDR student awards, International Award to PhD female student, and continuing strong collaborations with international health industry.

We were able to complete ten PhDs with four of them highly commended by examiners. Special thanks to CMRP postdoctoral researchers who have demonstrated outstanding performances, were able to prepare high-quality applications for Fellowships, IDEAS grants, space research grants, and awarded contracts from industry.

CMRP is active in commercialisation and continues clinical trials at St George CCC on advanced HDR brachytherapy treatment of prostate cancer utilising in vivo MOSkin dosimetry.

A highlight was the MMND ITRO 2020 international conference with more than 150 participants from many different countries around the world and the visit of AAPM CAMPEP team for the accreditation of our Medical Physics program.

We look forward to continuing CMRP’s outstanding performances in 2020 and beyond. 

Publications

Anatoly Rosenfeld, Saree Alnaghy, Marco Petasecca, Michael Lerch, Stanislav Pospisil, Valentina Giacometti, Reinhard Schulte, Valeria Rosso, Matthias Wurl, Carlos Granja, Mária Martišíková, Katia Parodi “Medipix detectors in radiation therapy for advanced quality-assurance”, Rad. Meas., Volume 130, January 2020, 106211, doi.org/10.1016/j.radmeas.2019.106211 (Invited Review)

Bolst, David; Guatelli, Susanna; Tran, Linh; Chartier, Lachlan; Davis, Jeremy; Biasi, Giordano; Prokopovich, Dale; Pogossov, Alex; Reinhard, Mark; Petasecca, Marco; Lerch, Michael; Matsufuji, Naruhiro; Povoli, Marco; Summanwar, Anand; Kok, Angela; Jackson, Michael; Rosenfeld, Anatoly “Validation of Geant4 for silicon microdosimetry in heavy ion therapy”, Phys. Med. Biol., 65(4), 2020, doi: 10.1088/1361-6560/ab586a

Z Jamalludin , W L Jong, R A Malik, A B Rosenfeld and N M Ung “Evaluation of rectal dose discrepancies between planned and in vivo dosimetry using MOSkin detector and PTW 9112 semiconductor probe during 60Co HDR CT-based intracavitary cervix brachytherapy”, Physica Medica, Dec 9;69:52-60, 2020. doi: 10.1016/j.ejmp.2019.11.025

Dirk Wagenaar, Linh T. Tran, Arturs Meijers, Gabriel Guterres Marmitt,  Kevin Souris, David Bolst, Benjamin James, Giordano Biasi, Marco Povoli. Angela Kok. Erik Traneus. Marc-Jan van Goethem, Johannes A. Langendijk, Anatoly B. Rosenfeld, Stefan Both “Validation of linear energy transfer computed in a Monte Carlo dose engine of a commercial treatment planning system”, Phys.Med. Biol., 65(2):025006, 2020 doi: 10.1088/1361-6560/ab5e97

David Bolst; Susanna Guatelli; Linh Tran; Anatoly Rosenfeld “The impact of sensitive volume thickness for silicon on insulator microdosimeters in hadron therapy”, Phys.Med Biol, 65(3), 2020. doi: 10.1088/1361-6560/ab623f

Sarah J. Alnaghy, Trent Causer, Natalia Roberts, Brad Oborn, Urszula Jelen, Bin Dong, Maegan Gargett, Jarrad Begg, Gary Liney, Marco Petasecca, Anatoly B. Rosenfeld, Lois Holloway, Peter Metcalfe, “High Resolution Silicon Array Detector Implementation in an Inline MRI-Linac”, Med.Phys.,47(4), 2020

S. Peracchi, B. James, L. T. Tran, D. Bolst, D. A. Prokopovich, J. A. Davis, S. Guatelli, M. Petasecca, M. L. F. Lerch, N. Matsufuji, A. Kok, M. Povoli and A. B. Rosenfeld “A solid-state microdosimeter for dose and radiation quality monitoring for astronauts in space”, IEEE Trans. On Nucl. Sci. NS-67(1), 169-174, 2020  DOI: 10.1109/TNS.2019.2943597

Benjamin James, Linh T. Tran, David Bolst, Stefania Peracchi, Jeremy A. Davis, Dale A. Prokopovich, Susanna Guatelli, Marco Petasecca, Michael Lerch, Marco Povoli, Angela Kok, Marc-Jan Goethem, Mitchell Nancarrow, Naruhiro Matsufuji, Michael Jackson and Anatoly B. Rosenfeld “SOI Thin Microdosimeters for High LET Single Event Upset Studies in Fe, O, Xe and Cocktail Ion Beam Fields”, IEEE Trans. On Nucl. Sci. NS-67(1), 146-153, 2020 DOI: 10.1109/TNS.2019.2939355

Andrew Chacon, Benjamin James, Linh Tran, Susanna Guatelli, Lachlan Chartier, Dale Prokopovich, Daniel Franklin, Akram Mohammadi, Fumihiko Nishikido, Yuma Iwao, Go Akamatsu, Soudai Takyu, Hideaki Tashima, Taiga Yamaya, Katia Parodi, Anatoly Rosenfeld, and Mitra Safavi-Naeini “Experimental investigation of the characteristics of radioactive beams for heavy ion therapy”, Med Phys. , 47(7), 3123-3132, 2020

Giordano Biasi, Fang-Yi Su, Taghreed Al Sudani, Marco Pestasecca, Michael Lerch, Vladimir L. Perevertaylo and Anatoly B. Rosenfeld “On the Combined Effect of Silicon Oxide Thickness and Boron Implantation Under the Gate in MOSFET Dosimeters”, IEEE Trans on Nucl. Sci., 67(3) , March, 2020

J. A. Posar, J. Davis, M. Large, L. Basiricò, A. Ciavatti, B. Fraboni, O. Dhez, D. Wilkinson, P. Sellin, M. J. Griffith, M. Lerch, A. Rosenfeld and M. Petasecca “Characterization of an Organic Semiconductor Diode for Dosimetry in Radiotherapy”, Med. Phys, May, 2020 doi:10.1002/mp.14229

David Bolst, Dean Cutajar, Susanna Guatelli, A. Le, Anatoly Rosenfeld et al.…. “Report on G4-Med, a Geant4 benchmarking system for medical physics applications, developed by the Geant4 Medical Simulation Benchmarking Group”, Med.Phys., 2020 doi.org/10.1002/mp.14226

Levi Madden, James Archer, Enbang Li, Urszula Jelen, Bin Dong, Lois Holloway, Anatoly Rosenfeld “MRI-LINAC beam profile measurements using a plastic scintillation dosimeter”, Physica Medica, 73, 111-116, 2020,

Rosenfeld, Anatoly; Biasi, Giordano; Petasecca, Marco; Lerch, Michael; Villani, Giulio; Feygelman, Vladimir “Semiconductor dosimetry in modern external-beam radiation therapy” PMB, 2020, Topical Review , (accepted 18th April, 2020) DOI:10.1088/1361-6560/aba163

Stefan Bartzsch, Stéphanie Corde, Jeffrey C Crosbie, Liam Day, Mattia Donzelli, Michael Krisch, Michael Lerch, Paolo Pellicioli , Lloyd M L Smyth and Moeava Tehei “Technical advances in x-ray microbeam radiation therapy” Topical Review, Phys. Med Biol , 65(2) 2020 https://doi.org/10.1088/1361-6560/ab5507

Owen J. Brace Sultan F. Alhujaili, Jason R. Paino, Duncan J. Butler, Dean Wilkinson, Brad M. Oborn, Anatoly B. Rosenfeld, Michael L. F. Lerch, Marco Petasecca, Jeremy A. Davis “Evaluation of the PTW microDiamond in edge‐on orientation for dosimetry in small fields”, JACMP, 20 April, 2020 DOI: 10.1002/acm2.12906

Rutherford, Harley; Chacon, Andrew; Mohammadi, Akram; Takyu, Sodai; Tashima, Hideaki; Yoshida, Eiji; Nishikido, Fumihiko; Hofmann, Theresa; Pinto, Marco; Franklin, Daniel; Yamaya, Taiga; Parodi, Katia; Rosenfeld, Anatoly; Guatelli, Susanna; Safavi-Naeini, Mitra “Dose quantification in carbon ion therapy using in-beam positron emission tomography”, Phys. Med. Biol., 2020 (accepted )

Andreas Tefre Samnøy, Kristian S. Ytre-Hauge, Linh Tran, Anatoly Rosenfeld, Marco Povoli, Angela Kok, and Summanwar, Eirik Malinen and Dieter Röhrich “Microdosimetry with a 3D silicon on insulator (SOI) detector in a low energy proton beamline” Radiation Physics and Chemistry, 176, June 2020, DOI: 10.1016/j.radphyschem.2020.109078

Elette Engels, Nan Li, Jeremy Davis, Jason Paino, Matthew Cameron, Andrew Dipuglia1, Sarah Vogel , Michael Valceski, Abass Khochaiche, Alice O’Keefe, Micah Barnes, Ashley Cullen, Andrew Stevenson, Susanna Guatelli, Anatoly Rosenfeld, Michael Lerch, Stéphanie Corde  & Moeava Tehei “Toward personalized synchrotron microbeam radiation therapy”. Scientific Reports, 10, article number:8833, doi.org/10.1038/s41598-020-65729-z

Abdella M. Ahmed, Andrew Chacon, Harley Rutherford,Go Akamatsu, Akram Mohammadi, Fumihiko Nishikido,Hideaki Tashima, Eiji Yoshida, Taiga Yamaya, Daniel R. Franklin, Anatoly Rosenfeld, Susanna Guatelli, Mitra Safavi-Naeini “A validated Geant4 model of a whole-body PET scanner with four-layer DOI detectors” Phys. Med. Biol., accepted June , 2020

Levi Madden; Alexandre Santos; Enbang Li; Raghu Gowda; Eva Bezak; Shahraam Afshar; Anatoly Rosenfeld “Temporal modelling of Beryllium Oxide Ceramics’ rtOSL for dosimetry with a superficial 140 kVp X-ray beam” , Physics Medica, 2020 (conditionally accepted)

Brennen, Taylah; Galli, Luca ; Cutajar, Dean; Alnaghy, Saree; Bucci, Joseph; Bece, Andrej; Enari, Komiti; Favoino, Marco; Carriero, Marco; Tartaglia, Marco; Archer, James; Lerch, Michael; Rosenfeld, Anatoly; Petasecca, Marco “BrachyView: Development of an Algorithm for Real-time Automatic LDR Brachytherapy Seed Detection”, Phys. Med. Biol., 2020 (accepted, July, 2020)

Fontanarosa, D., Benitez, J., Talkhani, S., Fielding, A., Entezam, A., Trapp, J., Moi, D., Biasi, G., Petasecca, M., Mazzieri, R. “A novel add-on collimator for preclinical radiotherapy applications using a standard cell irradiator: design, construction, and validation” 2020 Medical Physics 47(6), pp.2461-2471, DOI:10.1002/mp.14110

Matar, F.S., Wilkinson, D., Davis, J., Biasi, G., Causer, T., Fuduli, I., Brace, O., Stansook, N., Carolan, M., Rosenfeld, A.B., Petasecca, M. “Quality assurance of VMAT on flattened and flattening filter-free accelerators using a high spatial resolution detector” 2020 Journal of Applied Clinical Medical Physics 21(6), pp.44-52, DOI:10.1002/acm2.12864

Davis, J.A., Boscardin, M., Crivellari, M., Fanò, L., Large, M., Menichelli, M., Morozzi, A., Moscatelli, F., Movileanu-Ionica, M., Passeri, D., Petasecca, M., Piccini, M., Rossi, A., Scorzoni, A., Thompson, B., Verzellesi, G., Wyrsch, N. “Modeling a Thick Hydrogenated Amorphous Silicon Substrate for Ionizing Radiation Detectors” 2020 Frontiers in Physics, 8(158), DOI:10.3389/fphy.2020.00158

Posar, J.A., Davis, J., Brace, O., Sellin, P., Griffith, M.J., Dhez, O., Wilkinson, D., Lerch, M.L.F., Rosenfeld, A., Petasecca, M. “Characterization of a plastic dosimeter based on organic semiconductor photodiodes and scintillator”, 2020, Physics and Imaging in Radiation Oncology, Vol.14, pp. 48-52, DOI: 10.1016/j.phro.2020.05.007

Menichelli, M., Boscardin, M., Crivellari, M., Davis, J., Dunand, S., Fanò, L., Morozzi, A., Moscatelli, F., Movileanu-Ionica, M., Passeri, D., Petasecca, M., Piccini, M., Rossi, A., Scorzoni, A., Servoli, L., Verzellesi, G., Wyrsch, N. “Hydrogenated amorphous silicon detectors for particle detection, beam flux monitoring and dosimetry in high-dose radiation environment” 2020 Journal of Instrumentation, 15(4), C04005, DOI:10.1088/1748-0221/15/04/C04005

Griffith, M.J., Cottam, S., Stamenkovic, J., Posar, J.A., Petasecca, M. “Printable Organic Semiconductors for Radiation Detection: From Fundamentals to Fabrication and Functionality” 2020, Frontiers in Physics Vol 8(22), DOI:10.3389/fphy.2020.00022 (Invited Review)

Duncan, M., Donzelli, M., Pellicioli, P., Brauer-Krisch, E., Davis, J.A., Lerch, M.L.F., Rosenfeld, A.B., Petasecca, M. “First experimental measurement of the effect of cardio-synchronous brain motion on the dose distribution during microbeam radiation therapy” 2020 Medical Physics, Vol 47(1), pp.213-222, DOI:10.1002/mp.13899

Aswin Hoffmann, Bradley Oborn, Maryam Moteabbed, Susu Yan, Thomas Bortfeld, Antje Knopf, Herman Fuchs, Dietmar Georg, Joao Seco, Maria Francesca Spadea, Oliver Jakel, Christopher Kurz, and Katia Parodi. “MR-guided proton therapy: a review and a preview”. Radiation Oncology, 15(1):129, 2020.

Grants

Grant Name

Number

Submitted

NHMRC Investigator Grant

3

NHMRC Ideas

4

Cancer Australia PdCCRS

2

Cancer Council Project Grant

2

ARC DP

2

Cancer Institute NSW Early Career Fellowship

2

Australian Society of Aerospace Medicine, Space Travel grant on radiation shielding

1

Australian Space Agency

2

Joint International Grant : SA KAIMC-CMRP

1

Joint International Grant: IEAP Prague, SINTEF Norway & CMRP

1

Funding

CMRP has been successful in attracting funding from collaborators

ANSTO GRANTS

  • AP12632: Innovative microdosimeter system for radon dosimetry in Jenolan Cave, $69,000
  • AP12615: Characterisation of ultra-thin silicon and SiC microdosimeters for radiation therapy application, $90,000
  • AP12134: Effect of the irradiation on the electroactive properties of PLA
COMMERCIALISATION
Awards

100% Success with AINSE Scholarship https://news.eis.uow.edu.au/cmrp-continues-impressive-success-rate-with-ainse-scholarships-applications/ 

Phelps Continuing Education Award, Nuclear Space Radiation Effect Conference (IEEE NSREC) to PhD student Stefania Peracchi for research on microdosimetry studies or radiation shielding for space radiation 

Accreditation of Medical Radiation Medical Physics Program by American Association Physicists in Medicine (AAPM). Only one of three accredited medical physics programs outside of North America https://www.campep.org/campeplstgrad.asp

Conferences

CMRP CONFERENCES:

MMND ITRO 2020 https://cmrp.events/, more than 150 participants

Proceedings of MMND ITRO 2020 are ready, to be published by IOP:  39 papers

Completed PhD Theses

Name

Thesis Title

Sultan Fahad Alhujaili

Dosimetry and characterization of solid state detectors for medical dosimetry in IMRT and SRS

Mohammed Al Towairqi

Development of fiber-optic dosimetry system as a quality assurance tool for HDR Brachytherapy

James Archer

High spatial resolution fibre-optic dosimetry

Matthew Cameron

Microbeam Radiation Therapy: Development of Instrumentation and Software Tools for Quality Assurance

Andrew Chacon

Dose Quantification and Enhancements for Particle Therapy

Emily Debrot

Applications of silicon dosimeters and Monte Carlo simulations for physical and biological dose quality assurance in particle therapy

Mitchell Duncan

Dosimetry of Movable Targets in SRS

Joel Poder

Development of a system for comprehensive in-vivo validation of transrectal ultrasound based high dose rate prostate brachytherapy treatments.

Natalia Roberts

Dosimetry and 4D Modelling for Advanced Radiotherapy Treatments: Towards MRI-Guided Lung SBRT

Nathan Thorpe

Kilovolt Range Characterisation and Diagnostic Applications of the MOSkin Dosimeter