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Centre for Multidisciplinary Modelling Seminar
April 13, 2018 @ 11:30 am - 12:30 pm
This seminar is unusual in that the speaker is an undergraduate. Vivien had a summer placement at the Peter MacCullum Cancer Centre in Melbourne. In her presentation she will overview the work she carried out there!
School of Mathematics and Applied Statistics, UoW
Primary and metastatic tumour evolution
Cancerous tumours evolve in such a way that they acquire diverse genetic mutations. As a result, these tumours are highly heterogeneous and hence difficult to treat. In addition, these tumours may have acquired resistance mechanisms during their evolution, which allow them to metastasise elsewhere in the body. To examine the acquisition of this tumour heterogeneity (and hence their resistance mechanisms), we mathematically reconstruct clonal evolution using an adapted population dynamics model for both primary and metastatic tumours. It is hoped that this tumour evolution model will aid in the analysis of cancer patient data and in the development of optimal treatment strategies that target the specific heterogeneity of both primary and metastatic tumours.